exacerbation
1. [ noun ] action that makes a problem or a disease (or its symptoms) worse
Synonyms: aggravation
Examples:

"the aggravation of her condition resulted from lack of care"

Related terms: intensification worsen
2. [ noun ] violent and bitter exasperation
Examples:

"his foolishness was followed by an exacerbation of their quarrel"

Related terms: exasperation exacerbate
Similar spelling:   exacerbating
  execration
  exacerbate
  exaggeration