aggravation
1. [ noun ] unfriendly behavior that aggravates or irritates someone
Synonyms: provocation irritation
Related terms: aggression taunt twitting last_straw aggro harass
2. [ noun ] an exasperated feeling of annoyance
Synonyms: exasperation
Related terms: annoyance outrage
3. [ noun ] action that makes a problem or a disease (or its symptoms) worse
Synonyms: exacerbation
Examples:

"the aggravation of her condition resulted from lack of care"

Related terms: intensification worsen
Similar spelling:   aggravating
  aggravatingly
  aggravate
  aggravator
  aggravated